Anti-tumor promoting activity of bufadienolides from Kalanchoe pinnata and K. daigremontiana x tubiflora.

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Abstract

  1. Biosci Biotechnol Biochem. 2001 Apr;65(4):947-9.

Anti-tumor promoting activity of bufadienolides from Kalanchoe pinnata and K.
daigremontiana x tubiflora.

Supratman U(1), Fujita T, Akiyama K, Hayashi H, Murakami A, Sakai H, Koshimizu K,
Ohigashi H.

Author information:
(1)Division of Applied Biological Chemistry, Graduate School of Agriculture and
Life Sciences, Osaka Prefecture University, Sakai, Japan.

Five bufadienolides (1-5) isolated from the leaves of Kalanchoe pinnata and K.
daigremontiana x tubiflora (Crassulaceae) were examined for their inhibitory
effects on Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells
induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. All
bufadienolides showed inhibitory activity, and bryophyllin A (1) exhibited the
most marked inhibition (IC50 = 0.4 microM) among the tested compounds.
Bryophyllin C (2), a reduction analogue of 1, and bersaldegenin-3-acetate (3)
lacking the orthoacetate moiety were less active. These results strongly suggest
that bufadienolides are potential cancer chemopreventive agents.

DOI: 10.1271/bbb.65.947
PMID: 11388478 [Indexed for MEDLINE]