Polyketide Natural Products, Acetogenins from Graviola (Annona muricata L), its Biochemical, Cytotoxic Activity and Various Analyses Through Computational and Bio-Programming Methods.

Article about Soursop

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Abstract

  1. Curr Pharm Des. 2016;22(34):5204-5210.

Polyketide Natural Products, Acetogenins from Graviola (Annona muricata L), its
Biochemical, Cytotoxic Activity and Various Analyses Through Computational and
Bio-Programming Methods.

Prabhakaran K, Ramasamy G, Doraisamy U, Mannu J, K R, Murugesan JR(1).

Author information:
(1)Department of Plant Biotechnology, Centre for Plant Molecular Biology and
Biotechnology, Tamil Nadu Agricultural University, Coimbaore, India.
[email protected]

BACKGROUND: Plants became the basis of traditional medicine system throughout the
world for thousands of years and continue to provide mankind with new remedies.
Annona muricata, the plant of Annonaceae family, is also known as sour sop or
Graviola. In recent years, many compounds have been reported and have gained
organic chemist's and biochemist's attention because of their novel structure and
wide range of bioactivity. Local populations have used the bark, leaves, roots,
fruit, seeds and flowers for thousands of years to treat everything from
arthritis to liver problems. Annonaceous acetogenins found only in the Annonaceae
family kill malignant cells of 12 different types of cancer including Breast,
Ovarian, Colon, Prostate, Liver, Lung, Pancreatic and Lymphoma.
METHODS: Hence, the study was initiated to identify, fractionate and validate
compounds of pharmaceutical importance from the leaf extract. Research was made
for the phytochemical screening using different solvents and the metabolites were
screened using TLC.
RESULTS: The presence of acetogenins was confirmed using PMA 5% spray. The
anti-cancer activity studies were done for Breast Cancer cell lines, MCF-7 and
the cell inhibition activity was 98%. We were curious to study the computational
part of the aetogenins; hence, apart from the experimental studies, various
computational studies were progressed using Schrödinger and other computational
tools to validate the key target protein and the potent molecule "Coronin" and
Annonaine.
CONCLUSION: To predict and decipher the activity of various acetogenins in Annona
muricata and its potent activity towards the inhibition of cancer cell lines, it
is interesting to look out for the potent lead compound against the disease.

DOI: 10.2174/1381612822666160531163144
PMID: 27262333 [Indexed for MEDLINE]