Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata.

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Abstract

  1. Phytochemistry. 1998 Sep;49(2):565-71.

Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves
of Annona muricata.

Kim GS(1), Zeng L, Alali F, Rogers LL, Wu FE, Sastrodihardjo S, McLaughlin JL.

Author information:
(1)Department of Medicinal Chemistry and Molecular Pharmacology, School of
Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47906,
USA.

Bioactivity-directed fractionation of the leaves of Annona muricata L.
(Annonaceae) resulted in the isolation of two new Annonaceous acetogenins,
muricoreacin (1) and murihexocin C (2). Compounds 1 and 2 showed significant
cytotoxicities among six human tumor cell lines with selectivities to the
prostate adenocarcinoma (PC-3) and pancreatic carcinoma (PACA-2) cell lines.

DOI: 10.1016/s0031-9422(98)00172-1
PMID: 9747542 [Indexed for MEDLINE]