Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves
of Annona muricata.
Kim GS(1), Zeng L, Alali F, Rogers LL, Wu FE, Sastrodihardjo S, McLaughlin JL.
(1)Department of Medicinal Chemistry and Molecular Pharmacology, School of
Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47906,
Bioactivity-directed fractionation of the leaves of Annona muricata L.
(Annonaceae) resulted in the isolation of two new Annonaceous acetogenins,
muricoreacin (1) and murihexocin C (2). Compounds 1 and 2 showed significant
cytotoxicities among six human tumor cell lines with selectivities to the
prostate adenocarcinoma (PC-3) and pancreatic carcinoma (PACA-2) cell lines.
PMID: 9747542 [Indexed for MEDLINE]